Scott Halpern
University of Pennsylvania, PA·Medicine & Clinical Research·Early-career
Randomized clinical trials are how doctors learn which treatments work for people whose lungs fail. A trial's answer is only trustworthy if its participants resemble the patients who will later get the treatment.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
respiratory failure
randomized clinical trials
trial enrollment
- Grants
- 1 known grant, through Jun 2028
What they work on
- Test whether mobile patient recruitment strategies make enrollment in respiratory failure randomized trials more representative of the patients who would later receive the treatments.
- Test whether behavioral economic framing of consent decisions, which changes how the choice to join a trial is presented, improves the representativeness of respiratory failure trials.
- Conduct qualitative interviews with patients who have acute or chronic respiratory failure and are enrolled in prospective cohort studies, to understand their experiences.
- Determine whether the 7 most common risk-adjustment prediction models perform fairly across demographic groups, using patient-level data from 15 trials from the PAIR Center, ARDSNet and PETAL.
More about the research
It also depends on whether the scoring tools used to adjust for patients' baseline risk work equally well for everyone. This project studies both problems in trials for acute respiratory failure, a sudden breakdown of breathing, and for chronic, long-lasting respiratory failure.
Why it matters
Treatments for lung failure are judged by clinical trials. When trials under-enroll some groups, or use risk scores that work worse for some demographic groups, the evidence may not fit everyone it is applied to. Finding recruitment and consent methods that broaden enrollment, and showing where common risk models fall short, could make trial results more reliable for the full range of patients with acute and chronic respiratory failure.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jacqueline Kruser
University of Wisconsin-Madison, WI·Medicine & Clinical Research
Map how time-limited trials of mechanical ventilation are actually carried out in five ICUs, using focused ethnography of 50 trials in patients with acute respiratory failure.
Paula Aristizabal
University of California-San Diego, CA·Medicine & Clinical Research
Test whether COMPRENDO, a program in which trained parent peers give culturally and linguistically matched education during informed consent, increases enrollment of Hispanic children in therapeutic cancer trials compared with consent from the oncologist alone.
Jacqueline Stocking
University of California-Davis, CA·Medicine & Clinical Research·Early-career
Optimize and validate an automated, EHR-based model predicting postoperative respiratory failure, using surgical patient data from 2014 to 2021 and pre- and intra-operative risk factors.
The school
University of Pennsylvania: 90 labs on PI Pages, $2.2B a year on research, 750 research doctorates a year.
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