Kenneth Tew
Medical University of South Carolina, SC·Biochemistry
Oxygen lets cells make energy efficiently, but it also creates toxic byproducts called oxidants. To cope, organisms have evolved redox stress pathways, systems that sense and neutralize this oxidative damage.
- Fields
Biochemistry
Pharmacology
Medicine & Clinical Research
- Topics
redox biology
oxidative stress
redox signaling
- Grants
- 1 known grant, through Jul 2027
What they work on
- Strengthen the center's shared Analytical Redox, Proteomics (mass spectrometry and mass spectrometry imaging) and Cell & Molecular Redox Imaging cores so they serve the center's translational goals sustainably.
- Use a Pilot Projects Program to grow center membership and support new studies of how redox signaling, the cell's response to oxidants, drives human disease.
- Build research connections between the Redox COBRE and other national programs so the center becomes a lasting resource for redox biology across disciplines.
More about the research
When these pathways malfunction, they can contribute to diseases such as cancer, heart disease, neurodegeneration, diabetes, gut disorders and drug addiction. This center grant supports a group of researchers studying how redox imbalance causes disease, without limiting the work to any one disease.
Why it matters
Faulty oxidative-stress pathways play a role in cancer, cardiovascular and neurodegenerative diseases, diabetes, gastrointestinal disorders and drug addiction. A sustainable redox research center with shared analytical, proteomics and imaging facilities could help researchers find new therapies and interventions that target these pathways, which may eventually benefit patients with these conditions.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Drew Jones
New York University, NY·Biochemistry
Provide metabolomics services to cancer researchers, including global and untargeted metabolomics, lipidomics, mass spectrometry imaging and custom targeted methods for measuring specific metabolites.
Rebecca Hull-Meichle
University of Washington, WA·Medicine & Clinical Research
Provide diabetes researchers with expert consultation on study design, appropriate controls and interpretation of tissue changes, drawing on staff experience with diabetes-relevant tissues.
Kristofer Fritz
University of Colorado Denver/Anschutz Medical Campus, CO·Pharmacology
Characterize how chronic alcohol metabolism changes thiol redox signaling, the on-off switching of cysteine residues in proteins, in liver cells, using redox proteomics and bioinformatics.
The school
Medical University of South Carolina: 19 labs on PI Pages, $321M a year on research, 271 research doctorates a year.
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