Adam Krieg
Oregon Health & Science University, OR·Physiology
An egg matures inside a small fluid-filled sac in the ovary called a follicle. How follicles grow determines female fertility and the success of in vitro fertilization (IVF).
- Fields
Physiology
Medicine & Clinical Research
Biology
- Topics
anti-Müllerian hormone
folliculogenesis
ovarian follicle
- Grants
- 1 known grant, through Jun 2027
What they work on
- Test whether priming macaques of advanced reproductive age or with poor ovarian response with anti-Müllerian hormone (AMH) improves their response to gonadotropin stimulation and IVF outcomes.
- Determine whether adjusting AMH during culture improves follicle growth and egg maturation from vitrified-warmed macaque and human ovarian tissue.
- Define how AMH controls cell division and energy production in macaque preantral follicles grown at 5% oxygen, using AMH supplementation or knockdown and analysis of hypoxia-inducible factor, cell cycle and creatine pathways.
More about the research
Anti-Müllerian hormone (AMH), a hormone made by developing follicles, plays a key role. Its effect depends on the follicle's stage. The team's earlier work in rhesus macaques, monkeys whose reproduction closely resembles women's, showed that AMH promotes growth of early (preantral) follicles. At later (antral) stages, it holds back follicle maturation. Timing AMH treatment to the right stage improved follicle growth in the lab and produced eggs (oocytes) able to be fertilized.
Why it matters
Women of advanced reproductive age or with poor response to ovarian stimulation often have limited IVF success. Fertility preservation from frozen ovarian tissue is also still limited. Findings could help optimize IVF protocols and expand fertility preservation options, including for people who freeze ovarian tissue before treatments that harm fertility.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Amanda Kallen
University of Vermont, VT·Genetics
Chart the ovarian aging process in genetically diverse Collaborative Cross mouse strains with low Anti-Müllerian hormone and reduced fertility by measuring ovarian reserve, hormones, follicle development and molecular aging markers.
Zelieann Craig
University of Arizona, AZ·Physiology
Identify the tissues and molecular events that raise free fatty acid levels inside ovarian follicles of mice exposed to human-relevant phthalate mixtures, testing the role of the LXR-SREBP1c pathway that controls fat production.
Jose Suarez
University of California-San Diego, CA·Public Health & Epidemiology
Test whether insecticide and herbicide biomarkers in young women are linked to lower ovarian reserve, measured as anti-Müllerian hormone (AMH), and to altered thyroid hormones and testosterone in the ESPINA cohort.
The school
Oregon Health & Science University: 24 labs on PI Pages, $545M a year on research, 54 research doctorates a year.
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