Amanda Kallen
University of Vermont, VT·Genetics
The age at natural menopause affects more than fertility. Early menopause raises the risk of heart disease, osteoporosis, diabetes and cognitive decline.
- Fields
Genetics
Physiology
Medicine & Clinical Research
- Topics
ovarian aging
menopause
reproductive aging
- Grants
- 1 known grant, through Jun 2028
What they work on
- Chart the ovarian aging process in genetically diverse Collaborative Cross mouse strains with low Anti-Müllerian hormone and reduced fertility by measuring ovarian reserve, hormones, follicle development and molecular aging markers.
- Build a single-cell RNA sequencing atlas of the aging mouse ovary to find genes and pathways that differ between strains and may control reproductive lifespan.
- Identify candidate genetic regulators of ovarian aging to be tested later in functional studies and knockout mouse models.
More about the research
Later menopause is linked to a longer lifespan. Genes explain much of the variation in menopause timing, yet only about 30% of that genetic influence has been traced to specific DNA regions. Most of the genes that control ovarian aging remain unknown.
Why it matters
Finding the genes that set the pace of ovarian aging could help explain why some women reach menopause early and face higher risks of heart disease, bone loss and cognitive decline. Over the long term, these findings could guide personalized approaches to delaying menopause and protecting reproductive health and longevity.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Adam Krieg
Oregon Health & Science University, OR·Physiology
Test whether priming macaques of advanced reproductive age or with poor ovarian response with anti-Müllerian hormone (AMH) improves their response to gonadotropin stimulation and IVF outcomes.
Jose Suarez
University of California-San Diego, CA·Public Health & Epidemiology
Test whether insecticide and herbicide biomarkers in young women are linked to lower ovarian reserve, measured as anti-Müllerian hormone (AMH), and to altered thyroid hormones and testosterone in the ESPINA cohort.
Pauline Maki
Washington University in St Louis, MO·Neuroscience
Map longitudinal changes in brain structure, function, connectivity and memory across menopause stages in 220 women aged 40–59, staging menopause by bleeding criteria and anti-Müllerian hormone (AMH), and relating changes to estradiol.
The school
University of Vermont: 16 labs on PI Pages, $246M a year on research, 76 research doctorates a year.
Reach out
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