Bin Jiang
Northwestern University, IL·Biomedical Engineering
Vascular surgery has advanced greatly, yet one problem remains: the procedures damage the endothelium, the thin layer of cells lining blood vessels. That damage contributes to complications such as vein graft failure, restenosis (re-narrowing of a treated vessel) and thrombosis (blood clots).
- Fields
Biomedical Engineering
Medicine & Clinical Research
Physiology
- Topics
mitochondrial transplantation
mitochondrial therapy
endothelial repair
- Grants
- 1 known grant, through Apr 2030
What they work on
- Optimize the stem cell source of mitochondria, the storage formulation and the lipid-polymer-peptide surface coating so that engineered mitochondria are stable, scalable and practical to use during vascular surgery.
- Test whether engineered mitochondria improve repair of the endothelium, the vessel's inner lining, in a vein graft bypass model of open surgery, and map where the mitochondria travel in the body.
- Evaluate the therapeutic effect and body distribution of engineered mitochondria in a balloon angioplasty model of endovascular surgery, delivered during or after the procedure.
More about the research
No current surgical approach actively protects or regenerates the endothelium during or after an operation. One key driver of poor endothelial repair is dysfunction of mitochondria, the cell's energy-producing compartments.
Why it matters
Patients with cardiovascular disease who undergo bypass grafting or angioplasty often face graft failure, restenosis or clots caused by damage to the vessel lining. A storable mitochondrial therapy that fits into surgical procedures could help vessels heal and reduce these complications. In the long term, it may offer a broader way to preserve vascular health.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Daniel Engebretson
University of South Dakota, SD·Biomedical Engineering
Assess the translation potential of a drug-coated angioplasty balloon for peripheral and cerebrovascular artery disease through first-hand interviews and investigation of the medical device industry in the I-Corps program.
Lisa Rong
Weill Medical College of Cornell University, NY·Medicine & Clinical Research·Early-career
Compare how single versus multiple arterial grafting during bypass surgery changes heart function, measured as echo strain by transesophageal echocardiography, and whether changes relate to blood pressure-support drug use.
Brandon Tefft
Medical College of Wisconsin, WI·Biomedical Engineering
Identify signaling pathways that let a subset of endothelial cells stay attached under blood-like shear stress, using RNA sequencing to compare gene activity in all cells versus cells that remain attached.
The school
Northwestern University: 71 labs on PI Pages, $1.3B a year on research, 536 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.