Jonathan Overdevest
Columbia University, NY·Medicine & Clinical Research·Early-career
Losing the sense of smell is a common effect of COVID-19, and for many people it lasts a long time. Smell is tied closely to brain regions involved in memory and mood.
- Fields
Medicine & Clinical Research
Neuroscience
Public Health & Epidemiology
- Topics
olfactory dysfunction
smell loss
anosmia
- Grants
- 1 known grant, through May 2027
What they work on
- Identify epidemiologic risk factors for initial and persistent olfactory dysfunction after COVID-19 in a multi-ethnic patient cohort, using both self-reported and test-based smell measures.
- Test whether persistent smell loss after COVID-19 is associated with neurological, neurocognitive and neuropsychiatric problems, measured with the multilingual NIH Toolbox assessment battery.
- Generate pilot brain imaging data linking features of smell loss and neurological outcomes to anatomical and inflammatory changes in the brain.
More about the research
So lasting smell loss may signal wider problems with thinking, emotional health and quality of life. Still, it is unclear who is most at risk of post-viral smell loss and how it relates to brain function.
Why it matters
Knowing who is most likely to lose their sense of smell after COVID-19, and how that loss relates to memory, mood and daily functioning, could help clinicians counsel patients. It could also identify at-risk groups for preventive care. Brain imaging findings may later help track how the brain processes smell and monitor results of clinical trials for smell-loss treatments.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Daniel Beswick
University of California-Los Angeles, CA·Medicine & Clinical Research
Characterize chronic rhinosinusitis (CRS) and loss of smell in young children with cystic fibrosis, using validated, age-appropriate, non-invasive objective and subjective measures.
Bradley Goldstein
Duke University, NC·Neuroscience
Map the axes of gene-expression variation across human olfactory sensory neurons by single-cell RNA sequencing of nasal biopsies from people with normal smell and from people with objectively measured smell loss.
Thomas M Wisniewski
New York University, NY·Medicine & Clinical Research
Compare cognitive and neuropsychological performance yearly over five years among older adults with post-COVID cognitive symptoms, infected adults without symptoms and uninfected controls, using the CDR-SB and Uniform Data Set Version 3.
The school
Columbia University: 89 labs on PI Pages, $1.4B a year on research, 625 research doctorates a year.
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