PIPages
Labs

Anna Greenwald

Georgetown University, DC·Neuroscience

A stroke on the right side of the brain often damages visuospatial abilities. These include noticing things on one side of space, directing movements toward that side, sustaining attention, and copying or assembling shapes.

Fields

Neuroscience

Psychology

Medicine & Clinical Research

Topics

stroke

visuospatial deficits

spatial neglect

Grants
1 known grant, through Dec 2027

What they work on

  1. Test whether visuospatial deficits after right-hemisphere stroke reflect four separable core factors rather than one unitary 'spatial neglect', by giving stroke survivors and matched controls a comprehensive test battery analyzed with factor analysis.
  2. Identify the visuospatial tests most sensitive and specific to right-hemisphere stroke by comparing composite deficit scores between right- and left-hemisphere stroke survivors.
  3. Determine which core visuospatial deficits best predict functional ability and self-reported quality of life in long-term stroke survivors.
  4. Link specific lesion locations to specific deficits with lesion-symptom and functional-anomaly mapping on MRI, and test whether increased task-evoked activity in the undamaged hemisphere relates to performance.

More about the research

Such deficits strongly predict long-term disability. Yet they are less obvious than speech or movement problems, so they are often missed and untreated. Part of the problem is that researchers disagree on how to define them and use many different tests, which makes studies hard to compare.

Why it matters

Hundreds of thousands of people live with subtle but disabling visuospatial problems after brain injury, and current stroke screening tools underestimate right-brain damage. This work could produce a bedside-compatible test battery that catches these deficits. It could also identify which deficits rehabilitation should target, and guide noninvasive brain stimulation protocols that may strengthen the effects of behavioral therapy.

Known grants

From NIH and NSF research grants. Labs often have other funding we can't see.

Visuospatial deficits after stroke: Towards better classification, diagnostics, and rehabilitation.

NIH · Jul 2022 – Dec 2027

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Leonardo F Bonilha

University of South Carolina-Columbia, SC·Neuroscience

Test whether adding anodal transcranial direct current stimulation (tDCS) to audio-visual speech therapy improves naming more than sham stimulation, in a randomized Phase II/III trial of people with chronic Broca's aphasia.

Ying-Hui Chou

University of Arizona, AZ·Neuroscience

Determine whether excitatory or inhibitory rTMS, magnetic pulses delivered through the scalp and aimed at the hippocampus, improves memory more than sham stimulation, in a randomized crossover trial of 60 adults with amnestic mild cognitive impairment.

The school

Georgetown University: 14 labs on PI Pages, $377M a year on research, 206 research doctorates a year.

More about Georgetown University

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