Yan Cui
Augusta University, GA·Biochemistry
Dr. Yan Cui's research lab focuses on understanding how a specific pathway in the immune system affects head and neck cancers, particularly those that arise due to tobacco and alcohol use.
- Fields
Biochemistry
- Topics
head and neck cancer
immunosuppression
immune checkpoint
- Grants
- 1 known grant, through May 2028
What they work on
- Dissect how the CD73-A2BR pathway regulates the immune landscape in head and neck cancers.
- Develop effective CD73-adenosine-A2BR immunotherapy regimens in preclinical models.
- Assess the relationships between myeloid precursor levels and patient outcomes in head and neck cancer.
More about the research
The team studies how certain molecules in the tumor environment, like CD73 and its receptor A2BR, help tumors evade the immune system, making them harder to treat. By exploring these interactions, the lab aims to develop new therapies that can enhance immune responses against these aggressive cancers.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Andreas Wieland
Ohio State University, OH·Microbiology & Immunology
Generate dimeric IgA antibodies that target the HPV cancer-driving proteins E6 and E7, using a platform of human monoclonal antibodies isolated from B cells inside patients' tumors.
Thurl E. Harris
University of Virginia, VA·Physiology
Characterize how signaling through the A2B adenosine receptor (A2BR) in white fat changes between fasted and post-meal states, as receptor expression switches from A1R to A2BR.
Jun Wang
New York University, NY·Microbiology & Immunology
Determine whether Siglec-15, a tumor-associated immune brake, also suppresses myeloid cells such as macrophages, and identify the receptors it binds on myeloid cells and T cells.
The school
Augusta University: 11 labs on PI Pages, $166M a year on research, 37 research doctorates a year.
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