Richard A Flavell
Yale University, CT·Microbiology & Immunology
Dr. Richard Flavell's lab at Yale University focuses on studying Alcoholic Liver Disease (ALD), particularly Alcohol Associated Hepatitis (AAH), using advanced humanized mouse models.
- Fields
Microbiology & Immunology
- Topics
Alcoholic Liver Disease
Alcohol Associated Hepatitis
Humanized Mouse Models
- Grants
- 5 known grants, through May 2031
What they work on
- Examine NPC derived WNT4 and WNT10B signaling in hepatocyte antioxidant defense and bile acid synthesis.
- Investigate the role of NPC derived WNT2 and WNT5A in alcohol-induced steatosis and mitochondrial dysfunction.
- Study the impact of monocyte/macrophage subsets on hepatocyte steatosis and cholestasis.
More about the research
These models mimic human liver conditions better than traditional mouse models, allowing researchers to explore cellular interactions and metabolic changes in the liver that contribute to disease. The lab aims to uncover how specific signaling interactions between liver cells and immune cells are involved in AAH to identify potential treatment targets.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Functions and mechanisms of ILC2s in trained immunity
NIH · Jun 2026 – May 2031
PROJECT 3: Testing Pathobiology and Therapeutic Development in a Humanized Celiac Disease Mouse
NIH · Jun 2026 – Apr 2031
Non-parenchymalcells drive the key features of alcohol associated hepatitis (AAH) in a fully humanized mouse liver
NIH · Jun 2025 – Feb 2030
Closest labs
Xiaoqin Wu
University of Texas Health Science Center at Houston, TX·Microbiology & Immunology·Early-career
Characterize liver immune cell populations and cell death after Gao-binge alcohol feeding in Mlkl bone-marrow chimeric mice, using flow cytometry of isolated non-parenchymal liver cells.
Bernd Schnabl
University of California-San Diego, CA·Medicine & Clinical Research
Test whether the sugar-adding enzyme Fucosyltransferase 2 (Fut2) on intestinal lining cells limits colonization and translocation of the gut bacterium Enterococcus faecalis and thereby reduces liver disease, using mouse models of ethanol feeding.
Deepa Sathyaseelan
University of Oklahoma-Health Sciences Center, OK·Physiology
Determine whether necroptosis in hepatocytes, a cell death that spills inflammatory molecules like HMGB1, activates liver macrophages and drives liver inflammation, using mice in which necroptosis is turned on or off in hepatocytes.
The school
Yale University: 73 labs on PI Pages, $1.5B a year on research, 438 research doctorates a year.
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