Sammy Elmariah
University of California-San Francisco, CA·Medicine & Clinical Research
Aortic stenosis is a narrowing of the heart's main outflow valve that forces the heart muscle to work harder. It is common in older adults.
- Fields
Medicine & Clinical Research
Physiology
- Topics
aortic stenosis
valvular heart disease
aortic valve replacement
- Grants
- 1 known grant, through Feb 2027
What they work on
- Discover, test and cross-validate protein and metabolite (multi-omic) blood signatures that reflect heart structure and function in patients with severe aortic stenosis.
- Track how these multi-omic signatures change over time after aortic valve replacement and relate those changes to changes in heart structure and function.
- Evaluate how accurately multi-omic blood signatures predict which patients with severe aortic stenosis will improve after aortic valve replacement, to help guide the timing of surgery.
More about the research
Once symptoms appear, half of untreated patients die within a year. Replacing the valve, called aortic valve replacement (AVR), can relieve the problem. However, symptoms are often blamed on age or other illnesses, so treatment is delayed. Nearly half of patients who undergo AVR die within the first year or fail to improve. The team's research suggests that permanent damage and reshaping of the heart muscle, called remodeling, caused by delayed treatment drives these poor outcomes. Doctors lack objective tests to decide when to operate.
Why it matters
Many patients with aortic stenosis get valve replacement only after their heart muscle is permanently damaged. As a result, they keep their symptoms and face a higher risk of death. Blood-based early-warning markers could help cardiologists identify which patients need earlier surgery. This could reduce deaths and improve health after valve replacement in elderly patients with this common valve disease.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jiwon Kim
Weill Medical College of Cornell University, NY·Medicine & Clinical Research
Test whether right ventricle tissue injury, measured with high-resolution 3D LGE MRI (a scan that highlights scar) and extracellular volume mapping, predicts heart remodeling and worsening of the tricuspid leak in at least 265 patients with functional tricuspid regurgitation.
Peter Leary
University of Washington, WA·Medicine & Clinical Research
Test in a Phase 2, single-center, randomized placebo-controlled trial whether 24 weeks of valsartan, an angiotensin receptor blocker, is safe and improves six-minute walk distance in adults with pulmonary arterial hypertension.
Jessica Turnier
University of Michigan, MI·Medicine & Clinical Research·Early-career
Identify skin and blood gene expression signatures that predict treatment response in juvenile dermatomyositis, using non-invasive skin sampling of lesional and non-lesional skin in a longitudinal patient cohort.
The school
University of California-San Francisco: 89 labs on PI Pages, $2.1B a year on research, 164 research doctorates a year.
Reach out
A start for your email. Fill in the brackets.