Guillaume Madelin
New York University, NY·Biomedical Engineering
Standard MRI scanners image hydrogen nuclei (protons) in water and fat, which mainly reveals the structure of tissue. Sodium nuclei can also be imaged, and sodium levels reflect how well cells maintain their internal balance of ions, a sign of cell health.
- Fields
Biomedical Engineering
Medicine & Clinical Research
Physics
- Topics
sodium MRI
multinuclear MRI
MR fingerprinting
- Grants
- 2 known grants, through Nov 2027
What they work on
- Build a proton/sodium (1H/23Na) multichannel radiofrequency coil and optimize simultaneous multinuclear MR fingerprinting for bilateral breast MRI at 3 tesla, including Dixon water/fat and contrast-enhanced scans.
- Scan patients with triple-negative breast cancer before chemotherapy and within a week of the first and second cycles, tracking sodium-based metabolic, structural and contrast-uptake measures.
- Develop an imaging biomarker model combining sodium, structural and pharmacokinetic MRI metrics, and test which combinations best predict pathological response to neoadjuvant chemotherapy.
- Optimize simultaneous proton/sodium MR fingerprinting for knee cartilage, measuring water content and sodium-linked proteoglycan content as signs of cartilage integrity.
- Combine MRI, synovial fluid inflammation markers and biomechanical measures from ACL-injured patients to find a small biomarker set predicting post-traumatic osteoarthritis over 3–8 years.
More about the research
Both projects use a method the team developed that captures proton and sodium MRI data at the same time. It relies on MR fingerprinting (MRF), a fast technique that measures several tissue properties in one scan. Each project applies the method to a clinical problem where early warning signs are missed by standard imaging: breast cancer treatment response and joint damage after knee injury.
Why it matters
About 30% of patients with locally advanced breast cancer, including triple-negative breast cancer, respond poorly to pre-surgery chemotherapy. An early imaging marker could flag these patients so they can be considered for alternative therapy, sparing them unnecessary toxicity. For the more than 100,000 people per year in the US who tear an ACL, predictive markers could help identify therapeutic targets for arthritis. They could also help monitor treatments meant to prevent post-traumatic osteoarthritis.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
X. Lucas Lu
University of Delaware, DE·Biomedical Engineering
Determine whether statin use is linked to lower rates of osteoarthritis in the Delaware population, using a retrospective cohort study of existing health records.
Matthew B Fisher
North Carolina State University, NC·Biomedical Engineering
Determine how ACL reconstruction technique (epiphyseal, complete transphyseal or partial transphyseal, differing in how they cross the bone's growth plate) affects knee stability and joint degeneration at different stages of skeletal maturity, using a growing pig model.
Alexander Knights
Washington University in St Louis, MO·Medicine & Clinical Research·Early-career
Determine how Rspo2-driven Wnt/β-catenin signaling controls the appearance and behavior of scar-promoting synovial cells in PTOA, using transgenic reporter mice, multi-omic analyses and in vitro differentiation assays.
The school
New York University: 72 labs on PI Pages, $1.5B a year on research, 540 research doctorates a year.
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