Olga Chechneva
University of California-Davis, CA·Neuroscience
After birth, the brain's neurons keep maturing and gaining the properties they need for thinking and movement. When this process goes wrong, it can contribute to autism, cerebral palsy and epilepsy.
- Fields
Neuroscience
Biology
Genetics
- Topics
oligodendroglia
oligodendrocytes
neuron-glia interaction
- Grants
- 1 known grant, through Jun 2028
What they work on
- Identify which neurons receive material from satellite oligodendroglia during brain maturation, using spatial transcriptomics to profile single SOL-neuron nuclear pairs in the developing mouse cortex.
- Explore what triggers oligodendroglia-neuron material transfer by comparing SOL-neuron pairs in healthy cortex and under neuroinflammatory conditions that promote these interactions.
- Test whether satellite oligodendroglia transfer material to neurons through direct contact between nuclei, using two-photon live imaging to track SOL migration, contact, transfer and fate.
More about the research
Glial cells, the brain's support cells, help neurons mature, but the mechanisms are poorly understood. That gap makes it hard to design therapies that support healthy brain development.
Why it matters
Children with autism, epilepsy, cerebral palsy and other developmental delays may have disrupted neuron maturation. By describing a newly recognized way that glial cells supply material to maturing neurons, this work could reveal targets for future regenerative or supportive therapies that promote healthy brain maturation.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Eva S Anton
University of North Carolina at Chapel Hill, NC·Neuroscience
Discover how the developing mouse cortex maintains the balance between radial progenitors and intermediate progenitors, the stem-like cells that set neuron number and type, using cell-type-specific genetic models, live imaging and lineage tracing.
Marco Hefti
University of Iowa, IA·Neuroscience
Determine whether tau's interaction with NMDA receptors, signaling channels at nerve connections, is needed for human neurons to mature and grow dendrites, using tau knockout human neurons.
William S Talbot
Stanford University, CA·Neuroscience
Determine how newly identified positive and negative regulators of myelination control the wrapping of nerve fibers by oligodendrocytes during development, neural plasticity and remyelination, using zebrafish genetics and cellular analysis.
The school
University of California-Davis: 49 labs on PI Pages, $1.0B a year on research, 647 research doctorates a year.
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