Greg Harris
University of Cincinnati, OH·Biomedical Engineering
About 20 million Americans live with the effects of injuries to the peripheral nervous system, the nerves outside the brain and spinal cord. When an injury leaves a large gap in a nerve, recovery is very limited and no adequate treatment exists.
- Fields
Biomedical Engineering
Materials Science
Neuroscience
- Topics
peripheral nerve repair
peripheral nerve injury
nerve regeneration
- Grants
- 1 known grant, through Dec 2028
What they work on
- Quantify and control the electric potential generated by piezoelectric PVDF-TrFE scaffolds in response to remote ultrashock activation and mechanical stimulation.
- Analyze how Schwann cells, the support cells of peripheral nerves, integrate with PVDF-TrFE scaffolds combined with decellularized extracellular matrix and how their behavior changes in response.
- Evaluate in vivo whether the ultrashock-activated scaffold minimizes the immune response and repairs critical-sized peripheral nerve gaps.
More about the research
A key reason is that regrowing nerve fibers lose the guidance, alignment and chemical signals normally supplied by the extracellular matrix (ECM), the protein scaffold surrounding cells.
Why it matters
Patients with severe peripheral nerve injuries often never regain function, because large nerve gaps lack effective treatment. A remotely activated scaffold that supplies electrical, physical and chemical guidance while limiting immune reactions could offer surgeons a new way to bridge these gaps and improve recovery.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Metin Uz
Cleveland State University, OH·Biomedical Engineering
Design, fabricate and characterize a biodegradable piezoelectric platform with a flexible cuff electrode, measuring its electrical output and lab degradation profile to control stimulation conditions on the pudendal nerve.
Vivian Lee
University of Pennsylvania, PA·Neuroscience
Determine the role of NMDA receptors, glutamate-sensing receptors, in corneal nerve maintenance and regeneration by conditionally deleting them in sensory nerves or in Schwann cells, the nerves' support cells, in mice.
Jeffery Twiss
University of South Carolina-Columbia, SC·Neuroscience
Test whether KHSRP, an RNA-binding protein that destabilizes mRNAs, controls peripheral nerve axon regeneration through a mechanism within the neuron, building on faster regeneration seen in KHSRP knockout mice.
The school
University of Cincinnati: 18 labs on PI Pages, $740M a year on research, 275 research doctorates a year.
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