Jordan Green
Johns Hopkins University, MD·Biomedical Engineering
Many diseases could be treated by changing how cells behave, whether that means teaching immune cells to attack cancer, calming them in autoimmunity, or stopping blood vessels from overgrowing in the eye. Doing this safely depends on materials that deliver drugs or genetic instructions to the right cells and keep working over time.
- Fields
Biomedical Engineering
Materials Science
Microbiology & Immunology
- Topics
nanoparticles
biomaterials
immunoengineering
- Grants
- 2 known grants, through Apr 2029
What they work on
- Design and synthesize nanoparticles and biomaterials with tuned chemistry, physical properties and biologic surface coatings that deliver nucleic acids into specific immune cells, inside and outside the body.
- Genetically program dendritic cells, macrophages and T cells with these nanoimmunomaterials to boost or suppress antigen-specific immune responses, and evaluate them for cancer and autoimmunity.
- Determine how integrins αvβ3 and α5β1, cell-surface receptors, cooperate with growth-factor receptors to drive retinal and choroidal blood-vessel overgrowth and leakage, using the peptide AXT107 and new analogs.
- Test whether AXT107 microparticles injected into the suprachoroidal space at the back of the eye provide sustained release and prolonged suppression of abnormal vessel growth and leakage.
More about the research
The PI's grants apply biomaterials and engineered molecules to two such problems: reprogramming immune cells and treating eye diseases caused by leaky, abnormal blood vessels.
Why it matters
Immune-programming nanoparticles that reach specific immune cells could become tools for cancer immunotherapy and for treating autoimmune disease. For people with wet macular degeneration and diabetic eye disease, current therapy requires frequent eye injections and does not work well for everyone. A longer-lasting treatment that blocks more than one disease pathway could reduce treatment burden and may help preserve vision.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Yali Jia
Oregon Health & Science University, OR·Biomedical Engineering
Build a 1-MHz, 120° wide-field, high-resolution OCTA system with GPU real-time processing that captures reliable retinal blood-flow images in a single scan, without stitching images together.
Yannis Paulus
Johns Hopkins University, MD·Biomedical Engineering
Upgrade a combined photoacoustic microscopy, optical coherence tomography and fluorescence microscopy system to image rabbit eyes in real time, without harming the eye.
Katelyn Swindle-Reilly
Ohio State University, OH·Biomedical Engineering
Synthesize and characterize an investigational anti-inflammatory drug and load it into ROS-responsive polydopamine nanoparticles that release more drug under oxidative stress.
The school
Johns Hopkins University: 100 labs on PI Pages, $4.1B a year on research, 622 research doctorates a year.
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