Edward Graves
Stanford University, CA·Medicine & Clinical Research
Radiation therapy kills tumors, but it also damages healthy tissue nearby. This limits how much radiation patients can safely receive.
- Fields
Medicine & Clinical Research
Biomedical Engineering
Microbiology & Immunology
- Topics
radiation oncology
radiotherapy
radiation biology
- Grants
- 2 known grants, through Aug 2027
What they work on
- Determine whether loss of the complement receptor C5aR1 broadly protects normal intestine, salivary gland and lung tissue in mice treated with fractionated and hypofractionated radiotherapy.
- Define how C5aR1 inhibition protects irradiated tissue, testing an IL-10-dependent mechanism involving CX3CR1+ macrophages that support cell survival and blood-vessel growth.
- Test whether C5aR1 inhibition increases IL-10 secretion and dampens NF-κB signaling to enhance killing of colorectal tumor cells by radiation, in cell culture and animal models.
- Evaluate clinical-grade C5aR1 inhibitors for protecting normal tissues and sensitizing colorectal tumors to radiotherapy.
- Develop artificial intelligence and machine learning methods to automate tumor and tissue segmentation and radiation treatment planning for conformal image-guided small-animal radiotherapy.
More about the research
Widening this "therapeutic window" means making tumors more sensitive while protecting normal organs. That is the shared goal of the program project these two grants belong to. One grant tests a drug target that may do both. The other supplies the precise animal radiation methods the program's experiments depend on.
Why it matters
Patients receiving radiotherapy, including those with colorectal cancer, often suffer radiation injury to the bowel, salivary glands or lungs. Drugs that block the complement receptor C5aR1 could make tumors respond better while sparing these healthy tissues. Better automated planning for animal radiation studies could also make preclinical radiotherapy research more reliable.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Brian Marples
University of Rochester, NY·Medicine & Clinical Research
Provide cancer researchers with image-targeted animal irradiation, using dose-volume histogram planning and multiple integrated beams to deliver dose to tumors while sparing normal tissue, paired with confocal and multiphoton microscopy.
Erinn Rankin
Stanford University, CA·Pharmacology
Test whether FTO, an enzyme that removes m6A chemical tags from RNA, drives glutamine rewiring in VHL-deficient kidney cancer by raising levels of SLC1A5, the protein that imports glutamine into cells.
Rongxiao Zhang
University of Missouri-Columbia, MO·Biomedical Engineering
Build beam models for FLASH-capable linear accelerators, the machines that produce the radiation, so planning software can accurately predict the dose that ultra-high dose rate electron beams deliver.
The school
Stanford University: 87 labs on PI Pages, $1.6B a year on research, 739 research doctorates a year.
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