Jiangyang Zhang
New York University, NY·Biomedical Engineering
When a newborn's brain is deprived of oxygen and blood flow, an event called hypoxic ischemic (HI) insult, both white matter (the nerve fibers that connect regions) and grey matter (the nerve cell bodies) are damaged. HI injury is a major cause of infant death and long-term disability, and the only effective treatment is therapeutic hypothermia, deliberate cooling of the body.
- Fields
Biomedical Engineering
Neuroscience
Medicine & Clinical Research
- Topics
neonatal hypoxic ischemic injury
HI injury
therapeutic hypothermia
- Grants
- 1 known grant, through May 2029
What they work on
- Develop diffusion MRI methods that measure tissue microstructure and water exchange between inside and outside of cells in a neonatal mouse model of hypoxic ischemic injury, and validate them against histology.
- Use the new diffusion MRI measures to characterize the extent and severity of brain cell death and to predict which edema (swollen) regions will survive.
- Cross-validate the diffusion MRI markers against metabolite and lipid maps of the same injured brains obtained by mass spectrometry imaging.
- Apply the validated imaging techniques to mice treated with therapeutic hypothermia to measure its effects on injury progression and elucidate its neuroprotective mechanisms.
More about the research
Animal models are widely used to study how the damage unfolds and how cooling helps. This project builds imaging tools to follow that process in living animals.
Why it matters
Infants with oxygen-deprivation brain injury have only one proven treatment, cooling. Imaging measures that reveal cell death and predict whether swollen tissue will recover could help researchers design better interventions and track treatment response in preclinical studies, and may clarify how therapeutic hypothermia protects the newborn brain.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Adam W Anderson
Vanderbilt University, TN·Biomedical Engineering
Develop and validate improved methods for identifying and characterizing multiple fiber populations within a single imaging voxel, benchmarking them against current leading algorithms using confocal microscopy of squirrel monkey brain as ground truth.
Manideep Chavali
Oregon Health & Science University, OR·Neuroscience
Dissect how oligodendrocyte progenitor cells, the precursors of myelin-forming cells, regulate apelin signaling in the endothelial cells lining brain blood vessels, during normal white matter development and after neonatal hypoxic-ischemic injury, using genetic and pharmacological strategies.
Jens H Jensen
Medical University of South Carolina, SC·Neuroscience
Determine whether diffusional kurtosis imaging (DKI), an MRI method that measures water movement in tissue, can track brain microstructure changes in 3xTg-AD mice treated with the drug P021 from 2 to 18 months of age.
The school
New York University: 72 labs on PI Pages, $1.5B a year on research, 540 research doctorates a year.
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