Vikram Fielding-Singh
Stanford University, CA·Medicine & Clinical Research·Early-career
People with end-stage kidney disease, whose kidneys have essentially stopped working, are 16 times more likely to undergo surgery than patients with normal kidney function, and they face far higher risk of dying, having a heart attack or having a stroke around the time of an operation. Nearly all of them depend on hemodialysis, a machine treatment that filters waste and fluid from the blood.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
end-stage kidney disease
hemodialysis
perioperative medicine
- Grants
- 1 known grant, through Mar 2029
What they work on
- Evaluate how modifiable preoperative hemodialysis parameters relate to postoperative complications such as myocardial infarction, stroke, heart failure, arrhythmia and infection, using linked Medicare claims and dialysis-provider electronic health records.
- Identify which postoperative complications underlie adverse outcomes in surgical patients with end-stage kidney disease, applying advanced statistical methods to this national linked dataset.
- Conduct a pilot randomized trial of an intervention that controls the timing of hemodialysis before surgery, to establish feasibility for larger prospective trials.
More about the research
Despite this heavy surgical burden, there is little evidence on how best to perform dialysis in the run-up to surgery. This project aims to make surgery safer for this population by optimizing preoperative hemodialysis.
Why it matters
Patients with end-stage kidney disease who need surgery face unusually high rates of death, heart attack, stroke and infection. Identifying which preoperative dialysis practices, including timing, are associated with fewer complications could give clinicians concrete guidance and give policy makers evidence for care standards, while setting up the randomized trials needed to prove which practices actually reduce harm.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Kevin Erickson
Baylor College of Medicine, TX·Medicine & Clinical Research
Measure the uptake of telemedicine by nephrologists and advanced practice providers for in-center maintenance hemodialysis care after COVID-19 waivers, using large administrative dialysis databases.
Mariana Murea
Wake Forest University, NC·Medicine & Clinical Research
Compare catheter-free dialysis days, access-related infections and deaths after fistula versus graft placement in a randomized trial of 262 hemodialysis patients aged 65 and older at 6 sites.
Arthur Matas
University of Minnesota, MN·Medicine & Clinical Research
Compare the long-term risk of end-stage kidney disease (ESKD, kidney failure requiring dialysis or transplant) and death between living kidney donors and healthy matched controls from the Rochester Epidemiology Project, with over 40 years of follow-up.
The school
Stanford University: 87 labs on PI Pages, $1.6B a year on research, 739 research doctorates a year.
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