Bradley Gelfand
University of Virginia, VA·Physiology
Many major diseases come down to blood vessels growing too much, in the wrong place, or too little. The process of growing new vessels is called angiogenesis.
- Fields
Physiology
Microbiology & Immunology
Genetics
- Topics
angiogenesis
sexual dimorphism
sex differences
- Grants
- 1 known grant, through Feb 2027
What they work on
- Determine how sex chromosome complement and gonadal hormones each contribute to sex differences in ADCAI, the process by which IgG1 antibodies inhibit blood-vessel growth.
- Test whether DDX3Y, a gene on the Y chromosome, regulates ADCAI and explains why males show stronger antibody-driven angioinhibition than females.
- Quantify how sex affects ADCAI in human cells and human specimens, to judge its relevance to human vascular disease.
More about the research
Diseases tied to it include macular degeneration, peripheral artery disease, coronary artery disease, stroke, and heart failure. Many of these conditions differ between men and women in risk, severity, or best treatment, yet why sex matters for blood vessels is poorly understood. This project studies one sex-biased way the immune system restrains vessel growth.
Why it matters
Antibody-driven suppression of blood-vessel growth may help or harm depending on the disease. Understanding why it is stronger in males could open personalized, sex-specific ways to adjust angiogenesis. That could inform treatment of conditions such as macular degeneration, peripheral artery disease, coronary artery disease, and stroke.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Sanda Predescu
Rush University, IL·Medicine & Clinical Research
Validate that Xist, a long non-coding RNA that silences one X chromosome in females, is more highly expressed and active in female pulmonary arterial hypertension lung tissue and pulmonary artery endothelial cells.
Andrew Mongue
University of Florida, FL·Ecology & Evolution
Construct a global phylogeny of bagworm moths from field-collected species to count how many times extreme female sexual dimorphism, including winglessness and loss of legs and eyes, evolved independently.
Dogukan Mizrak
University of Michigan, MI·Medicine & Clinical Research
Define the molecular triggers and downstream effects of CART signaling in human aortic smooth muscle cells in vitro, testing whether it drives wall remodeling and medial calcification, mineral buildup that stiffens the artery.
The school
University of Virginia: 43 labs on PI Pages, $814M a year on research, 413 research doctorates a year.
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