Karen Gibbins
Oregon Health & Science University, OR·Medicine & Clinical Research
More than half of preventable stillbirths in the United States are caused by placental dysfunction, when the placenta fails to support the fetus well. The same problem also causes preeclampsia and fetal growth restriction.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
stillbirth
placental dysfunction
placental insufficiency
- Grants
- 1 known grant, through Apr 2030
What they work on
- Externally validate and update a clinical predictive model of individual placental dysfunction risk in a cohort of 640 pregnant people followed through pregnancy.
- Measure how much ultrasound and blood biomarkers of placental health, collected at three time points, improve prediction, and find the best combination to guide fetal testing and delivery timing.
- Conduct cost-effectiveness analysis using decision-analytic models of placental dysfunction prediction, with and without biomarkers, to guide antenatal surveillance and delivery decisions.
More about the research
Doctors can watch at-risk pregnancies more closely or recommend earlier delivery. These steps only help if high-risk pregnancies can be identified, and current guidelines that count individual risk factors do this poorly.
Why it matters
Better individual risk estimates could let clinicians target fetal monitoring and timing of delivery to the pregnancies most at risk. This could help prevent stillbirths caused by placental insufficiency and reduce harm from preeclampsia and fetal growth restriction. Cost-effectiveness data would inform how health systems adopt such tools.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
David Peters
University of Pittsburgh, PA·Genetics
Develop cell-free DNA methylation analysis of maternal plasma that predicts the clinical trajectory of pregnancies diagnosed with mild or severe preeclampsia.
Mana M Parast
University of California-San Diego, CA·Medicine & Clinical Research
Test whether villitis of unknown etiology (VUE) linked to fetal growth restriction has a distinct cellular profile of chronic immune responses and trophoblast or endothelial damage, using mass cytometry on banked placental tissue.
Cande Ananth
Rutgers University-New Brunswick, NJ·Public Health & Epidemiology
Build a linked birth database of about 16 million births in five U.S. states from 2000–2016, assigning each residence daily PM2.5 and its components, nitrogen dioxide, ozone, and weather measures.
The school
Oregon Health & Science University: 24 labs on PI Pages, $545M a year on research, 54 research doctorates a year.
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