PIPages
Labs

Jennifer Steel

University of Pittsburgh, PA·Medicine & Clinical Research

More than 18 million Americans are living with cancer, and about half report serious depression, pain, or fatigue — the three symptoms an NIH consensus statement identifies as the most common and most distressing in cancer care. These symptoms do more than make people feel worse: they are linked to lower quality of life, poorer adherence to cancer treatment, more unplanned hospital and emergency visits, higher costs, and shorter survival.

Fields

Medicine & Clinical Research

Public Health & Epidemiology

Psychology

Topics

cancer survivorship

depression

cancer pain

Grants
1 known grant, through Nov 2029

What they work on

  1. Evaluate whether CARES, an electronic health record-based screening and stepped collaborative care intervention, improves patient-centered outcomes such as health-related quality of life, in a cluster randomized trial of more than 34 outpatient oncology clinics.
  2. Conduct an implementation-focused process evaluation guided by the RE-AIM framework, identifying patient, clinician and organizational facilitators and barriers to engaging with CARES in routine cancer care.
  3. Examine the net costs and cost-effectiveness of CARES compared with standard care, building the economic case needed to disseminate the program beyond the trial site.
  4. Use artificial intelligence to monitor fidelity of the CARES intervention, verifying that screening and stepped collaborative care are delivered as designed across participating clinics.

More about the research

Many cancer centers have successfully set up routine screening for these symptoms, but screening alone has not fixed the problem, because only a small fraction of patients who screen positive and get referred actually start treatment. This project addresses that gap between detection and care.

Why it matters

Cancer centers already screen for depression, pain and fatigue, but most patients who screen positive never start treatment. If CARES proves effective and cost-effective in ordinary oncology clinics, it could change how screening and symptom treatment are delivered nationwide, benefiting people living with cancer through better quality of life and potentially fewer emergency visits and readmissions, while giving health systems cost data to justify the change.

Known grants

From NIH and NSF research grants. Labs often have other funding we can't see.

Hybrid Type I Cluster Randomized Effectiveness-Implementation Trial of CARES

NIH · Dec 2024 – Nov 2029

Closest labs

Katherine Courtright

University of Pennsylvania, PA·Medicine & Clinical Research

Test whether an automated needs-based palliative care trigger in the electronic health record increases hospital-free days and palliative consults compared with usual care, in a cluster-randomized trial of over 64,000 patients at 9 hospitals.

Ravi Parikh

Emory University, GA·Medicine & Clinical Research

Test in a randomized trial whether A-PACT, machine learning risk prediction paired with lay health worker phone outreach, reduces hospitalizations and intensive end-of-life care for patients with cancer.

Kathryn Taylor

Georgetown University, DC·Public Health & Epidemiology

Compare electronic quitline referral against a centralized health-system phone counseling plus nicotine replacement program for lung screening patients, measuring biologically verified quitting at 3 and 6 months.

The school

University of Pittsburgh: 83 labs on PI Pages, $1.5B a year on research, 403 research doctorates a year.

More about University of Pittsburgh

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