Paul George
Stanford University, CA·Biomedical Engineering
Stroke is a leading cause of death and long-term disability, yet most stroke survivors receive no medical therapy that helps them recover. Fast emergency treatments exist, but only a small share of patients qualify.
- Fields
Biomedical Engineering
Neuroscience
Medicine & Clinical Research
- Topics
stroke
neural stem cells
stem cell transplantation
- Grants
- 1 known grant, through Nov 2027
What they work on
- Determine how electrically stimulated neural stem cell transplants delivered on ElectricStem conductive polymer scaffolds recruit and alter the brain's own stem cells after stroke in rodents.
- Test how electrical stimulation of transplanted neural stem cells acts through stanniocalcin-2 (STC2), a secreted protein that supports cell survival, by raising or lowering STC2 in the cells and measuring recovery.
- Evaluate whether STC2 on its own could serve as a therapy that improves functional recovery after stroke in rodent models.
- Test whether the functional gains from the ElectricStem system seen in young adult rodents also occur in an aged rodent stroke model that better reflects typical patients.
More about the research
This project asks whether bioengineered materials combined with stem cells can boost the brain's own repair processes after a stroke.
Why it matters
Most stroke survivors have no medical treatment that improves their long-term recovery. By identifying recovery pathways such as STC2 and pairing stem cell transplants with electrical stimulation, this work could point toward new therapies that strengthen the brain's own repair, potentially benefiting older stroke patients living with lasting disability.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Gianluca Lazzi
University of Southern California, CA·Biomedical Engineering
Design and optimize electrical stimulation waveforms that can reprogram the structure of damaged neural networks, using both experiments and computational modeling.
Mark Goldberg
University of Texas Health Science Center at San Antonio, TX·Neuroscience
Test whether REST, a protein that silences neural growth genes, limits motor recovery after stroke by selectively inactivating it in motor cortex neurons of transgenic mice using viral vectors.
Hirotake Komatsu
University of California-San Francisco, CA·Biomedical Engineering
Build human islet organoids about 5 mm thick by layering parylene microcapillary mesh that carries oxygen from flowing culture medium, testing whether a dynamic culture system keeps the organoid core alive past the usual diffusion limit.
The school
Stanford University: 87 labs on PI Pages, $1.6B a year on research, 739 research doctorates a year.
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