Kaveh Laksari
University of California-Riverside, CA·Biomedical Engineering
An ischemic stroke happens when a blood vessel in the brain is blocked or badly narrowed, starving the brain tissue downstream of blood. It causes about 90% of strokes, and stroke is a leading cause of death and disability.
- Fields
Biomedical Engineering
Medicine & Clinical Research
Engineering
- Topics
acute ischemic stroke
cerebrovascular morphology
collateral circulation
- Grants
- 1 known grant, through Mar 2029
What they work on
- Develop and validate a fully automatic algorithm that extracts brain-vessel shape and geometry from MR and CT angiograms of acute ischemic stroke patients in real time.
- Characterize how cerebrovascular morphology, the shape and branching of brain vessels, changes after acute ischemic stroke and after reperfusion therapy that restores blood flow.
- Build predictive models that combine vessel features, a collateral index of backup blood supply, and admission clinical and imaging data to forecast major complications and long-term stroke outcomes.
More about the research
Treatments that reopen vessels, called reperfusion therapies, work best when given early. Doctors still struggle to predict which patients will respond, who will have major complications, and how patients will recover. One clue is the collateral network, backup vessels that can route blood around a blockage. A well-connected network is linked to smaller brain damage and better recovery. These vessels are small and tangled, however, which makes them hard to assess.
Why it matters
Fast, accurate predictions after acute ischemic stroke could help doctors, patients and families choose treatments, judge the likely benefit of vessel-reopening therapy, and anticipate complications. Using standard CT and MR angiograms that hospitals already collect, automated vessel analysis could add useful information without extra scans.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Timothy J Carroll
University of Chicago, IL·Biomedical Engineering
Test whether Sanguinate®, a pegylated bovine hemoglobin blood substitute bound to carbon monoxide, boosts leptomeningeal collateral blood flow and reduces infarct volume and growth in a controlled model of ischemic stroke.
Ipek Oguz
Vanderbilt University, TN·Biomedical Engineering
Develop custom handheld spectrally encoded coherence tomography and reflectometry (SECTR) hardware, an eye-imaging system combining OCT and surface reflectance, for point-of-care imaging of infant eyes.
Luka Pocivavsek
University of Chicago, IL·Biomedical Engineering
Develop a geometric classification of aortic shapes by using computer-vision tools to reduce CTA scans of normal and dissected aortas to distributions of shape index and curvedness, two measures of surface form.
The school
University of California-Riverside: 21 labs on PI Pages, $232M a year on research, 328 research doctorates a year.
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