Ling-shiang Chuang
Icahn School of Medicine at Mount Sinai, NY·Genetics
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, causes chronic inflammation of the gut. Many gene variants that raise IBD risk are known, but how they actually cause disease is often unclear.
- Fields
Genetics
Microbiology & Immunology
Medicine & Clinical Research
- Topics
inflammatory bowel disease
Crohn's disease
ulcerative colitis
- Grants
- 1 known grant, through Jun 2027
What they work on
- Profile perianal fistula tissue from Crohn's disease patients with single-cell multiome ATAC plus transcriptome and spatial transcriptomics, which measure open DNA, gene activity and location cell by cell.
- Test whether gut stem cells and blood monocytes are 'imprinted' by chronic inflammation, flares or remission, using rectal-derived enteroids (mini-guts) and serial blood leukocyte and platelet sampling.
- Compare multi-omic data across IBD cohorts at GWAS risk loci, focusing on WNT signaling, AP-1 and reactive oxygen species, and contribute patient recruitment to the IBD Genetics Consortium.
More about the research
This project, a Genetics Research Center within a national IBD genetics consortium, asks how these risk genes act within specific cell types and tissue neighborhoods. A key cell type is the monocyte, a white blood cell that can mature into other cell types.
Why it matters
Perianal fistulae are a major unmet need for people with Crohn's disease, causing substantial illness with few effective treatments. By linking IBD risk genes to specific cell types and states, this work could point to mechanisms behind fistula formation and drug non-response. These insights may eventually inform new therapies. The center also aims to reduce health disparities through genetics research across diverse patient populations.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Jacob L Mccauley
University of Miami, FL·Genetics
Expand enrollment of a deeply phenotyped IBD cohort across South Florida and the wider state, substantially increasing the Hispanic genetic sample collection in the US for Crohn's disease and ulcerative colitis.
Arianne Theiss
University of Colorado Denver/Anschutz Medical Campus, CO·Microbiology & Immunology
Define how mitochondrial dysfunction expands CD74-positive inflammatory Paneth cells and disrupts gut balance, using mice lacking the mitochondrial protein PHB1 only in Paneth cells, which develop spontaneous ileitis.
Sana Syed
Duke University, NC·Medicine & Clinical Research·Early-career
Build a computational metabolic network reconstruction specific to the ileum, the part of the small intestine most affected by Crohn's disease, to serve as a reference model of healthy and diseased gut metabolism.
The school
Icahn School of Medicine at Mount Sinai: 45 labs on PI Pages, $1.0B a year on research, 62 research doctorates a year.
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