Maxim Mokin
University of South Florida, FL·Medicine & Clinical Research
When a weakened blood vessel in the brain bursts, blood spills into the space around the brain—a stroke called aneurysmal subarachnoid hemorrhage. Surviving the initial bleed is only part of the danger.
- Fields
Medicine & Clinical Research
Biomedical Engineering
Neuroscience
- Topics
subarachnoid hemorrhage
aSAH
intracranial aneurysm
- Grants
- 1 known grant, through Aug 2029
What they work on
- Test whether continuous bedside optical monitoring predicts outcomes after aneurysmal subarachnoid hemorrhage, measuring cerebral blood flow and an index of cerebrovascular autoregulation with pathlength resolved diffuse correlation spectroscopy throughout acute hospitalization.
- Determine whether this depth-sensitive optical instrument can detect patients developing delayed cerebral ischemia, the focal neurological or cognitive deficit that affects 30-50% of patients and most often appears four to ten days after rupture.
- Use the device for real-time monitoring of cerebral blood flow changes during drug treatments and endovascular procedures given to treat delayed cerebral ischemia, to judge whether each intervention is effective.
More about the research
Days later, roughly 30 to 50% of patients develop delayed cerebral ischemia: new weakness, confusion or both, caused by brain tissue not getting enough blood. It is the strongest predictor of poor recovery, and it usually strikes between days four and ten. The suspected cause is cerebral vasospasm, a narrowing of brain arteries. Existing ways to spot it—ultrasound through the skull, catheter-based angiography, or perfusion scans—each have limits, and none can watch the brain continuously at the bedside. The central idea of this project is that continuous bedside monitoring of brain blood flow and its regulation can both predict outcomes, including delayed cerebral ischemia, and show whether a treatment is working.
Why it matters
Delayed cerebral ischemia after a ruptured brain aneurysm causes much of the lasting disability and death from this type of stroke, and clinicians currently lack a way to monitor the brain continuously at the bedside. A noninvasive optical monitor that tracks brain blood flow and its regulation could identify the patients at highest risk, or catch the complication in its earliest stages, allowing earlier treatment and letting physicians see in real time whether a drug or catheter procedure is restoring blood flow.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Christopher G. Favilla
University of Pennsylvania, PA·Medicine & Clinical Research
Validate an optical algorithm for detecting large vessel occlusion by performing a 70-second speckle contrast optical spectroscopy blood flow scan on consecutive patients evaluated for acute stroke within 24 hours at three emergency departments, with urgent vascular imaging as the gold standard.
Brian Hoh
University of Florida, FL·Medicine & Clinical Research
Determine whether tocilizumab, an antibody blocking the IL-6 receptor, or resveratrol, a SIRT1 activator, improves neurological outcome after subarachnoid hemorrhage in a three-site, blinded, randomized animal trial.
Michael Johnson
University of Utah, UT·Medicine & Clinical Research
Determine how EPACC, a partly inflated, automatically controlled aortic balloon catheter, affects heart function and the rate of re-arrest during the first 24 hours after resuscitation in a pig model of cardiac arrest.
The school
University of South Florida: 20 labs on PI Pages, $522M a year on research, 305 research doctorates a year.
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