PIPages
Labs

Norah C Feeny

Case Western Reserve University, OH·Psychology

Stressful, destabilizing life events can trigger both posttraumatic stress disorder (PTSD) and depression. The two conditions often occur together, in up to 60% of cases.

Fields

Psychology

Medicine & Clinical Research

Topics

posttraumatic stress disorder

depression

major depressive disorder

Grants
1 known grant, through Jul 2027

What they work on

  1. Test in an open trial of 45 people whether PATH, a six-session therapy, reduces unproductive event processing, avoidance and reward-processing deficits in people with persistent symptoms after a destabilizing life event.
  2. Compare PATH with progressive muscle relaxation in a randomized trial of 135 participants to see whether the changes in these target processes replicate in a larger sample.
  3. Measure whether PATH reduces PTSD and depression symptoms compared with relaxation training, using event-focused revisiting and meaning-making along with work on positive and future events.

More about the research

Talk therapies for each work well for many people, but many patients drop out, a large minority keep serious symptoms, and some relapse under new stress. Most treatments target one disorder at a time and rarely build up the positive processes linked to resilience. This project develops and tests a brief therapy aimed at psychological processes shared by both conditions.

Why it matters

PTSD and depression after stressful events carry a large human and economic cost. A short, six-session therapy that works on processes common to both could reduce dropout, improve engagement and results, and help people stay well when future stressors arrive. The trials may also show which psychological processes drive recovery, which could guide more precise treatments.

Known grants

From NIH and NSF research grants. Labs often have other funding we can't see.

Treatment of Stress-Related Psychopathology: Targeting Maladaptive and Adaptive Event Processing

NIH · Jul 2020 – Jul 2027

Closest labs

Susan Whitfield-Gabrieli

Northeastern University, MA·Psychology

Test whether mindfulness-based real-time fMRI neurofeedback engages its intended brain target by reducing hyperconnectivity within the default mode network, the circuit active during inward self-focused thought, in adolescents aged 13 to 18 with major depressive disorder.

Douglas F Zatzick

University of Washington, WA·Medicine & Clinical Research

Test whether a brief stepped care intervention, combining care management, medication and psychotherapy, reduces PTSD symptoms over 12 months compared with required screening and referral, in a randomized trial of 424 hospitalized injury survivors.

Tatiana Davidson

Medical University of South Carolina, SC·Psychology

Test whether the Trauma Resilience and Recovery Program, a stepped-care model with text-message symptom tracking, improves quality of life and emotional recovery in 300 injured adolescents aged 12–17.

The school

Case Western Reserve University: 34 labs on PI Pages, $643M a year on research, 213 research doctorates a year.

More about Case Western Reserve University

Reach out

A start for your email. Fill in the brackets.