E. Jane Hubbard
New York University, NY·Biology
As we age, our stem cells lose function. This contributes to reproductive decline, tissue breakdown and cancer.
- Fields
Biology
Genetics
- Topics
stem cell niche
aging
germline stem cells
- Grants
- 1 known grant, through Jun 2031
What they work on
- Identify the molecular mechanisms by which insulin/IGF-like signaling acts from other tissues to drive age-related decline of the one-cell germline stem cell niche in C. elegans.
- Determine how other aging pathways affect the aging niche and the germline stem cells that respond to it, using genetic, imaging and -omic approaches in live worms.
- Uncover the mechanisms that control age-related changes in the nucleus of the niche cell, using cell biological imaging in worms of different ages.
More about the research
Stem cells are maintained by a niche, nearby cells that physically contact the stem cells and send them signals, and the niche ages too. How aging changes the shape of niche cells, and of cells in general, is poorly understood. That gap matters for regenerative therapies that place new stem cells into an aged body.
Why it matters
Learning how a stem cell niche ages in a simple worm system can inform similar processes in humans. That knowledge could help explain age-related loss of fertility and tissue maintenance, degenerative disease and cancer. It could also help predict how stem cell replacement therapies perform when placed into an aged tissue environment.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Lauren Anllo
East Carolina University, NC·Biology
Identify the signaling intermediaries that connect Slit and FGF signals from visceral muscle to expression of islet, a gene-regulating protein that directs niche cell movement, in the Drosophila embryonic testis.
Anthony De Tomaso
University of California-Santa Barbara, CA·Biology
Establish Botrylloides diegensis as a model in which stem cell dormancy can be switched on by cold, heat, starvation or low oxygen and reversed, using live imaging of the vascular mat that survives.
Jennifer Watts
Washington State University, WA·Genetics
Identify genes and pathways that control ferroptosis triggered by dietary polyunsaturated fatty acids in C. elegans germ cells, using genetic, dietary and biochemical approaches.
The school
New York University: 72 labs on PI Pages, $1.5B a year on research, 540 research doctorates a year.
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