Rachel Beekman
Yale University, CT·Medicine & Clinical Research
After a person is revived from cardiac arrest, the biggest factor in whether they survive with good brain function is how much brain damage was caused by the loss of oxygen and blood flow. This damage is called hypoxic-ischemic brain injury (HIBI).
- Fields
Medicine & Clinical Research
Neuroscience
Biomedical Engineering
- Topics
cardiac arrest
hypoxic-ischemic brain injury
portable MRI
- Grants
- 1 known grant, through Jul 2027
What they work on
- Measure how well low-field portable MRI agrees with conventional high-field MRI in detecting hypoxic-ischemic brain injury, comparing ratings across readers in 60 cardiac arrest survivors.
- Determine the positive predictive value and specificity of diffusion-weighted imaging lesions on ultra-early (within 6 hours) and early (12–24 hours) portable MRI for predicting HIBI on conventional MRI.
- Chart how HIBI changes over time and across brain regions with serial bedside portable MRI, identifying early findings that persist on later imaging.
More about the research
Some of it happens during the arrest itself, and some builds up over the following days. Treatments to limit that later damage are hard to develop without early ways to measure the injury. Standard high-field MRI can detect it, but critically ill patients often cannot be moved to the scanner.
Why it matters
Patients resuscitated from cardiac arrest often have brain injury that is hard to measure early. Bedside portable MRI could make imaging available to far more of these patients. Early imaging markers could help predict outcomes and serve as intermediate endpoints, which may in turn improve the design of clinical trials testing brain-protecting treatments.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
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The school
Yale University: 73 labs on PI Pages, $1.5B a year on research, 438 research doctorates a year.
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