Bani Mallick
Texas A&M University-College Station, TX·Mathematics & Statistics
Nearly every body process, from sleep and metabolism to hormone release, follows a roughly 24-hour circadian rhythm. A brain region called the suprachiasmatic nucleus (SCN) acts as the master clock.
- Fields
Mathematics & Statistics
Computer Science
Genetics
- Topics
Bayesian statistics
spatial transcriptomics
single-cell RNA sequencing
- Grants
- 1 known grant, through Jun 2028
What they work on
- Develop flexible Bayesian spatial clustering methods for single-cell spatial transcriptomics data to find how circadian rhythm disruption changes the mix of cell types in mammary tissue.
- Identify cell-type-specific spatially varying genes, genes whose activity shifts across the tissue within one cell type, to reveal how circadian disruption affects mammary development at the level of genes and cells.
- Build efficient R and Python software packages that implement the new Bayesian spatial methods, to be released and regularly updated for statistics and biomedical researchers.
More about the research
It sends nerve and hormone signals that keep clocks in other tissues, such as the liver and mammary glands, in time. Studies of large populations link circadian rhythm disruption (CRD), such as from shift work or travel across time zones, to metabolic, heart and mood disorders. How CRD changes the mammary gland's tissue environment at the molecular level is not known.
Why it matters
Many people work night shifts or travel across time zones. This work could show whether the resulting circadian disruption affects mammary gland development, and could identify key genes and changes in how cells communicate. The resulting Bayesian methods and free R/Python software could also help other researchers analyze spatial single-cell data in many tissues.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Eran Andrechek
Michigan State University, MI·Genetics
Characterize mammary gland defects in mice lacking E2F5 only in mammary epithelial cells, including duct extension during puberty, alveolar development and involution.
Matteo Pellegrini
University of California-Los Angeles, CA·Computer Science
Process bulk, single-cell and spatial transcriptomic data for consortium projects using established pipelines, and return interpretable results to collaborators without extensive computational expertise.
Marmar Moussa
University of Oklahoma, OK·Computer Science·Early-career
Model and predict which T-cell receptors are activated by neoepitope vaccination in MethA and MC38 mouse tumor models, using single-cell TCR sequencing paired with DNA-barcoded peptide–MHC dextramers that report what each cell binds.
The school
Texas A&M University-College Station: 23 labs on PI Pages, $1.4B a year on research, 768 research doctorates a year.
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