Katharine McGinigle
University of North Carolina at Chapel Hill, NC·Medicine & Clinical Research
Chronic limb-threatening ischemia (CLTI) is the most severe form of peripheral artery disease, in which blocked leg arteries starve tissue of blood. It causes wounds, amputations and early death.
- Fields
Medicine & Clinical Research
Public Health & Epidemiology
- Topics
chronic limb-threatening ischemia
peripheral artery disease
vascular surgery
- Grants
- 1 known grant, through May 2029
What they work on
- Identify patient traits linked to different disease courses and treatment patterns after the first blood-flow-restoring procedure, using machine learning on data from the 1,830-patient BEST-CLI trial.
- Measure how partially missing follow-up visits affects clinical trajectories and amputation-free survival in patients with chronic limb-threatening ischemia, using BEST-CLI trial data.
- Find barriers, supports and unmet needs that affect whether CLTI patients follow their treatment plans, using semi-structured interviews and journey mapping, a method that charts each step of a patient's care experience.
More about the research
Treatment combines medication, wound and foot care, and procedures to restore blood flow. Even with good options, outcomes remain poor. Patients' social and economic situations, how well they take their medicines, how well the procedure works, and whether they can attend follow-up visits all change results. How these factors shape the sequence of treatments a patient needs is poorly understood.
Why it matters
Patients with chronic limb-threatening ischemia face high risks of wounds, amputation and death. Treatment plans tailored to their medical and social needs could help them keep their limbs and live longer. The project aims to deliver testable treatment algorithms that show vascular surgeons where to adjust care and where patients need added support, such as help attending follow-up visits.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Shipra Arya
Stanford University, CA·Medicine & Clinical Research
Test whether greater market competition among surgeons is associated with higher rates of guideline-discordant small abdominal aortic aneurysm repair and tibial interventions for claudication, using linked Vascular Quality Initiative–Medicare and Veterans Health Administration data.
Laura Hansen
Emory University, GA·Physiology
Test whether muscle satellite cells are required for exercise-driven recovery of blood flow, using a mouse exercise preconditioning model in which satellite cells are selectively ablated.
Albert Sinusas
Yale University, CT·Medicine & Clinical Research
Develop a multimodality imaging approach that uses early bright regions on non-contrast CT to guide hydrogel injection through the chest wall into injured heart muscle, in a pig model of reperfused heart attack.
The school
University of North Carolina at Chapel Hill: 72 labs on PI Pages, $1.6B a year on research, 523 research doctorates a year.
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