Nancy Brady
University of Kansas, KS·Psychology
Fragile X syndrome (FXS) is an inherited condition that affects development, communication and behavior. Little is known about how young people with FXS fare as they leave school and enter adulthood, or how their mothers fare during this transition.
- Fields
Psychology
Medicine & Clinical Research
Social Science
- Topics
fragile X syndrome
FMR1 premutation
intellectual disability
- Grants
- 1 known grant, through Jun 2027
What they work on
- Determine how early factors such as parenting, communication, autism symptoms and biomarkers, and later factors such as transition plan quality, predict employment, independence and quality of life in young adults with fragile X syndrome.
- Examine how child behavior and maternal mental health and biomarkers predict changes in premutation mothers' executive functioning, anxiety, depression and caregiver burden during their child's transition to adulthood.
- Use up to 10 longitudinal data points per mother-child pair, from age 2 to 26, to identify possible treatment targets and the best timing for interventions.
More about the research
Many of these mothers carry the premutation, a smaller change in the same gene, and are facing their own aging. Earlier work by this team showed that FXS traits arise partly from interactions among biology, behavior and environment over time.
Why it matters
Identifying what predicts employment, independence and quality of life for young adults with fragile X syndrome could guide when and how to intervene for those at risk of poorer outcomes. Tracking mothers' mental health and caregiver burden could inform support for families and improve school transition planning.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
Megumi J Okumura
University of California-San Francisco, CA·Medicine & Clinical Research
Test whether the Resilience in Action (RiA) curriculum improves self-determination, self-efficacy, social confidence and emotional regulation in a randomized waitlist-control trial of 288 young adults with autism aged 19 to 26.
Robert Crosnoe
University of Texas at Austin, TX·Social Science
Document whether exposure to family member deaths in childhood and adolescence predicts unstable trajectories of socioeconomic attainment, family-building, and health in young adulthood, using longitudinal causal-inference techniques on the National Longitudinal Study of Adolescent to Adult Health.
Julie Wargo Aikins
Wayne State University, MI·Psychology
Test whether disrupted maternal representations of the child, measured with the Working Model of the Child Interview, stay stable from the third trimester of pregnancy to when the child is two years old, in 99 women living in high-risk settings.
The school
University of Kansas: 26 labs on PI Pages, $546M a year on research, 351 research doctorates a year.
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