Yue Guan
Emory University, GA·Public Health & Epidemiology
A short questionnaire about family history can flag women at high risk for cancers tied to inherited changes in the BRCA genes. National guidelines and public health organizations endorse this kind of brief, low-cost screening.
- Fields
Public Health & Epidemiology
Medicine & Clinical Research
- Topics
hereditary cancer
BRCA-associated cancers
family history screening
- Grants
- 1 known grant, through Jun 2028
What they work on
- Adapt Georgia's statewide family history screening program for BRCA-associated cancers at multiple levels, guided by the Exploration, Preparation, Implementation and Sustainment framework, to maximize sustainable reach and improve risk communication.
- Compare the adapted and current programs in a cluster randomized controlled trial in up to 6 Southwest Georgia public health clinics, measuring screening uptake and correct interpretation of results among women aged 25 and older.
- Test whether the adapted program increases uptake of risk-matched follow-up, such as genetic consultation and testing for high-risk women and appropriate breast imaging for lower-risk women.
- Evaluate reach, fidelity, and barriers and facilitators to program implementation and sustainability using the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance).
More about the research
Public health departments can reach women often left out of advances in cancer genetics, such as uninsured and rural residents. Georgia is one of the few states with statewide family history screening for BRCA-associated cancers. However, its clinic-based approach reaches limited numbers of women and is hard to sustain. Follow-up cancer screening is also low and is offered only to women found to be at high genetic risk.
Why it matters
Rural and uninsured women in Georgia often miss out on genetic cancer risk assessment and the prevention it enables. A more sustainable, wider-reaching screening program could help more of them learn their risk and get appropriate follow-up care. The findings are meant to guide rollout across all 187 Georgia public health clinics and could improve how other genomic services reach rural, underserved communities.
Known grants
From NIH and NSF research grants. Labs often have other funding we can't see.
Closest labs
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The school
Emory University: 70 labs on PI Pages, $1.2B a year on research, 286 research doctorates a year.
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